IMPORTANT SAFTEY INFORMATION ABOUT REYATAZ^® (atazanavir sulfate)

INDICATION: REYATAZ (atazanavir sulfate) is a prescription medicine used in combination with other medicines to treat people who are infected with the human immunodeficiency virus (HIV). REYATAZ has been studied in 48-week trials in both patients who have taken or have never taken anti-HIV medicines.

REYATAZ does not cure HIV or help prevent passing HIV to others.

IMPORTANT SAFETY INFORMATION: Do not take REYATAZ if you are taking the following medicines: ergot medicines, Versed^®, Halcion^®, Orap^®, Propulsid^®, Camptosar^®, Crixivan^®, Mevacor^®, Zocor^®, rifampin, St. John's wort, AcipHex^®, Nexium^®, Prevacid^®, Prilosec^® or Protonix^®. Do not use Viagra^®, Levitra^®, Cialis^®, Vfend^®, Advair^®, Flonase^®, or Flovent^® while you are taking REYATAZ without first speaking with your healthcare provider. This list of medicines is not complete. Discuss all prescription and non-prescription medicines, vitamin and herbal supplements, or other health preparations you are taking or plan to take with your healthcare provider.

Tell your healthcare provider right away if you have any side effects or conditions, including the following:

• A change in the way your heart beats may occur and could be a symptom of a heart problem.
• Diabetes and high blood sugar may occur in patients taking protease inhibitor medicines like REYATAZ.
• Yellowing of the skin and/or eyes may occur due to increases in bilirubin levels in the blood (bilirubin is made by the liver).
• Rash (redness and itching) sometimes occurs in patients taking REYATAZ, most often in the first few weeks after the medicine is started, and usually goes away within two weeks with no change in treatment.
• If you have liver disease, including hepatitis B or C, your liver disease may get worse when you take anti-HIV medicines like REYATAZ.
• Some patients with hemophilia have increased bleeding problems with protease inhibitor medicines like REYATAZ.

Changes in body fat have been seen in some patients taking anti-HIV medicines. The cause and long-term effects are not known at this time.

Other side effects of REYATAZ taken with other anti-HIV medicines include: nausea, headache, stomach pain, vomiting, diarrhea, depression, fever, dizziness, trouble sleeping, numbness, and tingling or burning of hands or feet.

You should take REYATAZ once daily with food (a meal or snack). You should take REYATAZ and your other anti-HIV medicines exactly as instructed by your healthcare provider.